Friday, 20 September 2013

MTI - 504 INTERMEDIARY METABOLISM II

UNIT 1: Lipid metabolism and disorders
Oxidation of saturated and unsaturated fatty acids, β oxidation. role of a carnitine,
ketogenesis and utilization. Biosynthesis of fatty acids, Metabolism of
Triglycerides Phospholipids and Sphingolipids, cholesterol biosynthesis,
regulation, transport, excretion, reverse cholesterol transport, formation of bile
acids, lipoprotein metabolism. Disorders of lipid metabolism – plasma lipids and
lipoproteins, abnormalities -hypo and hyper cholesterolemia, lipidosis, clinical
inter relationship of lipids. Clinical inter-relations ships of lipids (sphigolipidosis,
multiple sclerosis) ,lipoproteins and apolipopeoteins, Inherited metabolic lipid
disorders – Taysach’s disease, Niemannpick’s disease,ganglisidosis ,hypo and
hyper lipo proteinemia.

UNIT 2: Protein Metabolism and disorders
General reactions –transamination, deamination, decarboxylation, ammonia
formation urea cycle, metabolic breakdown of aminoacids to amphibolic
intermediates, conversion of aminoacids to specialized products – serotonin,
aminobutyric acid,dopamine, epinephrine ,norepinephnine ,melanin ,creatinine
and creatine, biosynthesis of non-essential aminoacids, key role of glutamate
dehydrogenase in nitrogen metabolism. Disorders of protein metabolism –
hperammonemia, phenylalaninemia, alkptonuria, phenylketonuria,
homocystinuria,cysteinemia,tyrosinemia and related disorders of aminoacidurias,
Hartnups disease.

UNIT 3: Metabolism of Nucleotides and disorders
Purine and pyrimidine nucleotide biosynthesis and catabolism regulation of
purine and pyrimidone nucleotide biosynthesis. Disorders of nucleotide
metabolism

UNIT 4: Metabolism of porphyrins
Biosynthesis and Degradation of porphyrins, heme , bile pigment formation,
transport and excretion.Porphyrias.

UNIT 5: Integration of metabolism
Inter-relationship of carbohydrate, protein and fat metabolism – role of acetyl
CoA. and TCA cycle in the inter-relationship, interconversion of major
foodstuffs. Regulation of intermediary metabolism .

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